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Community Q&A: Diabetic Patients’ Questions and Answers

Why do two different persons with same hba1c get different increase in blood glucose even though they consume same meal in same amount?

Blood glucose response to a meal can vary among individuals, even if they have the same HbA1c levels and consume the same meal in the same amount. Several factors can contribute to this variability:

Insulin sensitivity

Individuals differ in their sensitivity to insulin, a hormone that helps regulate blood glucose levels. Some people may have better insulin sensitivity, which means their body can effectively process and utilize glucose from the meal, resulting in a lower increase in blood glucose levels.

Metabolic rate

Each person has a unique metabolic rate, which affects how quickly their body metabolizes and processes nutrients. Differences in metabolism can influence the rate at which glucose is absorbed, utilized, or stored, leading to varying blood glucose responses.

Individual tolerance

People may have different tolerances to specific types of carbohydrates or other components of the meal. For example, some individuals may experience a larger blood glucose increase after consuming foods with a higher glycemic index (GI), which indicates how quickly a carbohydrate-containing food raises blood glucose levels.

Digestive differences

Factors related to digestion, such as the rate of stomach emptying, enzymatic activity, and absorption efficiency, can vary among individuals. These differences can impact how quickly carbohydrates are broken down into glucose and enter the bloodstream.

Gut microbiome

The composition of gut bacteria varies among individuals and can influence how carbohydrates are metabolized and absorbed. The gut microbiome can play a role in regulating blood glucose levels and may contribute to variations in individual blood glucose responses.

Stress and other factors

Emotional stress, physical activity levels, medication use, and other factors can influence blood glucose levels. These variables can vary between individuals and affect how the body responds to a meal.

It’s important to note that HbA1c reflects the average blood glucose levels over a span of several weeks and is not a real-time measurement of post-meal glucose response. Factors such as genetics, lifestyle, and overall diabetes management can contribute to differences in blood glucose responses among individuals with similar HbA1c levels.

Managing blood glucose levels requires individualized care, including medication, dietary choices, physical activity, and regular monitoring. Working closely with a healthcare team, including a healthcare provider and a registered dietitian, can help you understand your specific blood glucose responses and develop strategies to optimize your diabetes management.

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